For laboratory research use only. Not for human or veterinary use, and not evaluated by the FDA. Documentation shown is supplier-provided.
01 · The vial
Labelled with compound, concentration, lot, and research-use-only status.
Longevity Research
MOTS-c
40mg, with its supplier Certificate of Analysis published before you order. Without sourcing roulette, unlabelled vials, or crypto-only checkout.
- Supplier COA on every batch, published on this page, readable before you pay.
- Identity you can verify, CAS 1627580-64-6, molecular formula and weight listed, cross-checkable on PubChem.
- No testing claims we cannot back, Provyd runs no in-house testing and says so, documentation is supplier-provided.
- Card checkout, US dispatch, tracked, shipment protection included on every order.
For in-vitro laboratory research use only. Not for human or veterinary use.
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For laboratory research use only. Not for human or animal use.
Questions on documentation? Open the COA Center
48
Studies cited
every DOI verified
12
Compounds documented
with primary literature
99%+
Supplier-stated purity
per batch COA
100%
Orders tracked
shipment protection included
Before you order
Is documentation included?
Yes, a supplier COA is published for every batch and can be viewed before you order.
Do you test it yourselves?
No. Provyd runs no in-house or independent testing, and all documentation is supplier-provided.
Is this for human use?
No. Every compound is sold strictly for in-vitro laboratory research.
How fast does it ship?
Orders dispatch from the US with tracking, typically within one business day of ordering.
Can I pay by card?
Yes, standard card checkout with a verified researcher account, and no crypto is required.
What if it arrives damaged?
Shipment protection covers replacement, with the details set out in our guarantee.
Certificate of Analysis
Certificate of Analysis
Supplier-provided documentation
The details below reflect what a supplier COA reports. Provyd does not run its own laboratory testing and does not claim independent or third-party verification. Read every value as a supplier statement, and confirm it against the document supplied with your order.
- Purity (HPLC)
- As stated on supplier COA
- Identity (MS)
- Mass-confirmed on supplier COA
- Net peptide content
- As stated on supplier COA
- Heavy metals
- Per supplier documentation
- Sterility
- Per supplier documentation
- Endotoxin
- Per supplier documentation
Placeholder structure shown for demonstration. Specific purity percentages and lot numbers appear only on the supplier document itself, not as Provyd-tested figures.
View COA CenterInspect it yourself
Six things worth checking on any research-chemical order, and what you get here versus what the category typically does.
Provyd
Aluminium crimp seal intact and unbroken, stopper embossed. A seal that arrives compromised is grounds for replacement.
Typical research-chemical vendor
Loose or re-crimped caps are common, with no stated policy if the seal arrives broken.
Describes common practices in the research-chemical category, not any specific company. Provyd performs no independent or third-party testing, and all documentation referenced is supplied by the manufacturer.
Frequently researched together
Sibling concentrations and adjacent references researchers commonly study alongside this one.
Compound information
MOTS-c 40mg is listed in Provyd's Longevity Research catalog for laboratory research use only. Documentation is displayed as supplier-provided unless otherwise stated.
Researchers commonly compare against
- Sibling concentrations of the same compound
- Adjacent Longevity Research references
- Vehicle and control materials
- Supplier-provided documentation and lot records
Molecular profile
- Type
- Longevity Research
- Compound
- MOTS-c
- Concentration
- 40mg
- CAS number
- 1627580-64-6
- Molecular formula
- Not listed
- Molecular weight
- 2174.6 g/mol
- Sequence
- 16-amino-acid mitochondrial peptide
Reference identifiers are shown for research reference only. Verify them against the supplier-provided COA.
Storage & stability
Store according to the supplier-provided documentation. Keep sealed, protected from light, and logged against lot and concentration in your inventory records.
Published literature
Peer-reviewed research on this compound, cited so you can read the primary sources yourself. Every DOI and PMID below was checked to resolve.
State of the evidence
Animal and in-vitro data only for administered MOTS-c. Human studies identified measure endogenous circulating MOTS-c levels as a biomarker and do not involve administration of the peptide; no human interventional efficacy trials of MOTS-c administration identified.
- Animal preclinicalCell Metabolism · 2015
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, et al.
In mice, MOTS-c treatment prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity, acting via inhibition of the folate cycle and de novo purine biosynthesis leading to AMPK activation.
- Animal preclinicalAmerican Journal of Physiology - Endocrinology and Metabolism · 2021
MOTS-c reduces myostatin and muscle atrophy signaling
Kumagai H, et al.
MOTS-c prevented palmitic acid-induced atrophy in differentiated C2C12 myotubes and decreased plasma myostatin in diet-induced obese mice, with plasma MOTS-c inversely correlated with myostatin in human subjects.
- Animal preclinicalBiochimica et Biophysica Acta - Molecular Basis of Disease · 2021
MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway
Yang B, et al.
In C2C12 myotubes and mice, recombinant MOTS-c supplementation combined with exercise upregulated PGC-1α expression and improved insulin resistance and glucose metabolism via AMPK signalling.
- Human observationalJournal of Applied Physiology · 2021
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans
von Walden F, et al.
In 30 participants randomized to endurance exercise, resistance exercise or control, endogenous circulating MOTS-c and humanin levels were measured before and after exercise; no MOTS-c was administered in this study.
These references are provided as scientific context on the compound for qualified researchers. They describe published research findings, not results from Provyd products, and are not a representation that any product will produce any outcome. Provyd sells materials for in-vitro laboratory research use only. Nothing here is medical advice or an endorsement of human or veterinary use.
Catalog Experience Reviews
Reviews cover ordering, documentation, labeling, shipping, and support, not product outcomes.
Demo seed reviews, not verified customer outcomes
Clear labeling
Clean labeling and easy documentation access. The page made concentration comparison straightforward.
Packaging and records tidy
Packaging was tidy and the included order records matched the catalog listing exactly.
Simple, well-organized page
Well-organized product page. Research category and supplier-provided documentation status were easy to read.
Our guarantee
Ordered with confidence, or we make it right
Four commitments that cover how your order arrives and what documentation comes with it. Materials are supplied for laboratory research use only.
Shipment protection on every order
If your order is damaged, lost, or stolen in transit, we replace it at no cost to you.
Documentation guarantee
If the supplier COA for your batch turns out to be unavailable, you get a full refund.
Labelling accuracy
If the vial does not match the compound and concentration shown on the listing, we replace it or refund it.
Claims window and evidence
Send photo evidence within 10 days of delivery. Opened or reconstituted vials are not eligible.
Provyd runs no in-house or independent testing. All documentation referenced here is supplier-provided.
Important research notice
All products sold by Provyd are intended strictly for in-vitro laboratory research use only. They are not for human or animal consumption and are not drugs, foods, cosmetics, or dietary supplements. They are not intended to diagnose, treat, cure, or prevent any disease and have not been evaluated by the U.S. Food and Drug Administration. Documentation shown is supplier-provided unless otherwise stated.